منابع مشابه
S100 protein family in human cancer.
S100 protein family has been implicated in multiple stages of tumorigenesis and progression. Among the S100 genes, 22 are clustered at chromosome locus 1q21, a region frequently rearranged in cancers. S100 protein possesses a wide range of intracellular and extracellular functions such as regulation of calcium homeostasis, cell proliferation, apoptosis, cell invasion and motility, cytoskeleton ...
متن کاملThe S100 protein family and its application in cardiac diseases.
The S100 protein family is the largest group of EF-hand signaling proteins in humans. The members of the S100 protein family are expressed in many tissues and play different functions. Many diseases are related to S100 proteins, which function as new biochemical markers especially in cardiac diseases. The most studied members, protein S100B and protein S100A1, exhibit activities in cardiac dise...
متن کاملCalcium-dependent and -independent interactions of the S100 protein family.
The S100 proteins comprise at least 25 members, forming the largest group of EF-hand signalling proteins in humans. Although the proteins are expressed in many tissues, each S100 protein has generally been shown to have a preference for expression in one particular tissue or cell type. Three-dimensional structures of several S100 family members have shown that the proteins assume a dimeric stru...
متن کاملUnique S100 target protein interactions.
Three-dimensional structures of S100B, S100A1, S100A6 and S100A11 have shown that calcium binding to these proteins results in a conformational change allowing them to interact with many biological targets. The structures of some S100 proteins in the presence of peptide targets from Ndr kinase, p53, CapZ, annexins A1 and A2 and the Siah-1 Interacting Protein indicate there are at least three mo...
متن کاملMultiple Evolutionary Origins of Ubiquitous Cu2+ and Zn2+ Binding in the S100 Protein Family
The S100 proteins are a large family of signaling proteins that play critical roles in biology and disease. Many S100 proteins bind Zn2+, Cu2+, and/or Mn2+ as part of their biological functions; however, the evolutionary origins of binding remain obscure. One key question is whether divalent transition metal binding is ancestral, or instead arose independently on multiple lineages. To tackle th...
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ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2012
ISSN: 1768-3262
DOI: 10.4267/2042/46019